西洛他唑对稳定型心绞痛患者脂联素和内皮素-1及一氧化氮的影响Effect of Cilostazol on Patients with Stable Angina Pectoris Adiponectin and Endothelin-1 and Nitric Oxide
周小波;范学荣;郭宏伟;张爱军;
摘要(Abstract)：
目的观察西洛他唑对稳定型心绞痛患者血清脂联素(APN)、内皮素-1(ET-1)和一氧化氮(NO)的影响。方法将86例稳定型心绞痛患者随机分为观察组和对照组,各43例。两组患者除治疗原发病、调脂、稳定斑块、对症等治疗外,对照组予以拜阿司匹林片口服,观察组予以西洛他唑片口服,疗程均为12周。观察两组患者治疗期间心绞痛发作次数以及治疗前后血APN、ET-1及NO的变化。结果治疗期间两组患者心绞痛发作次数和硝酸甘油用量比较,差异无统计学意义(P>0.05)。观察组治疗后血清APN、NO水平高于对照组,血清ET-I水平低于对照组,差异均有统计学意义(P<0.05)。结论西洛他唑不仅有良好的抗栓作用,而且具有升高血清APN,调节血浆NO和ET-1平衡,从而发挥抗动脉粥样硬化及保护血管内皮功能的功效。
关键词(KeyWords)： 西洛他唑;心绞痛,稳定型;脂联素;内皮素;一氧化氮
基金项目(Foundation):
作者(Author): 周小波;范学荣;郭宏伟;张爱军;
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DOI:
参考文献(References)：
- 1 Kumada M,Kihara S,Sumitsuji S,et al.Association of hypoadipone-ctinemia with coronary artery disease in men[J].Arterioscler ThrombVase Biol,2003,23(1):85-89.
- 2 Huang Y,Cheng W,Wu J,et al.Cilostazol versus aspirin for second-ary ischemic stroke prevention cooperation investi gatom cilostazol alter n-ative to aspirin after isehaemic stroke:arandomised,double,blind,pilot study[J].Lancet Neuro,2008,7(6):494-499.
- 3 Banach M,Rysz J,Goch A,et al.The role of trimetazidine after a-cute myocardial infarction[J].Curr Vasc Pharmacol,2008,6(4):282-291.
- 4 Chazov EI,Lepakchin VK,Zharova EA,et al.Trimetazidine in angi-na combination therapy the TACT study:trimetazidin eversus convention-al treatment in patientswith stable angina pectoris in a randomized,pla-cebo controlled,multicenter study[J].American Journal of Therapeu-tics,2005,12:35-42.
- 5 Luscher TF.Endothelium derived relaxing and on tracting factors:cpote-ntial role in coronary artery disease[J].European Heart Journal,2008,10(2):847.
- 6 Aronow WS.Drug treatment of peripheral arterial disease in the elderly[J].Drugs Aging,2006,23(1):1-12.
- 7 Lugnier C.Cyclic nucleotide phosphod iesterase(PDE)superfamily:anew target for the development of specific therapeutic agents[J].Phar-macol Ther,2006,109(3):366-398.
- 8 Pischon T,Girman C,Hotamisligil GS,et al.Plasma adiponectin lev-elsand risk of myocardial infarction in men[J].JAMA,2004,291(14):1730-l737.
- 9 Armstrong EJ,Morrow DA,Sabatine MS.Inflammatory biomarkers inacute coronary syndromes partⅡ:acute phase reactants and biomarker-sof endothelial cell activation[J].Circulation,2006,113:152-155.
- 10 Schalkwijk CG,Stehouwer CD.Vascular complication in diabetersmellitus:the role of endothelial dysfunction[J].Clin Sci(Lond),2005,109:143-159.
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