西洛他唑对稳定型心绞痛患者脂联素和内皮素-1及一氧化氮的影响Effect of Cilostazol on Patients with Stable Angina Pectoris Adiponectin and Endothelin-1 and Nitric Oxide
周小波;范学荣;郭宏伟;张爱军;
摘要(Abstract):
目的观察西洛他唑对稳定型心绞痛患者血清脂联素(APN)、内皮素-1(ET-1)和一氧化氮(NO)的影响。方法将86例稳定型心绞痛患者随机分为观察组和对照组,各43例。两组患者除治疗原发病、调脂、稳定斑块、对症等治疗外,对照组予以拜阿司匹林片口服,观察组予以西洛他唑片口服,疗程均为12周。观察两组患者治疗期间心绞痛发作次数以及治疗前后血APN、ET-1及NO的变化。结果治疗期间两组患者心绞痛发作次数和硝酸甘油用量比较,差异无统计学意义(P>0.05)。观察组治疗后血清APN、NO水平高于对照组,血清ET-I水平低于对照组,差异均有统计学意义(P<0.05)。结论西洛他唑不仅有良好的抗栓作用,而且具有升高血清APN,调节血浆NO和ET-1平衡,从而发挥抗动脉粥样硬化及保护血管内皮功能的功效。
关键词(KeyWords): 西洛他唑;心绞痛,稳定型;脂联素;内皮素;一氧化氮
基金项目(Foundation):
作者(Author): 周小波;范学荣;郭宏伟;张爱军;
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DOI:
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