光超;桑道乾;

• 1:蚌埠医学院第一附属医院神经内科

摘要(Abstract)：

临床孤立综合征(CIS)是指首次发作的中枢神经系统急性或慢性脱髓鞘改变,持续时间>24 h,可累及中枢神经系统各个部位,最终进展为多发性硬化(MS)。CIS的主要临床表现包括认知障碍、视神经损伤、构音障碍、排便障碍等,行颅脑MRI检查可见异常信号,脑脊液检查可见脑脊液Ig G寡克隆带。本文报道了1例以睡眠障碍为主要临床表现的CIS患儿并分析了其诊治过程,供临床参考。

关键词(KeyWords)： 中枢神经系统疾病;儿童;睡眠障碍;病例报告

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 光超;桑道乾;

Email:

DOI:

参考文献(References)：

• [1]MILLER D H,CHARD D T,CICCARELLI O.Clinically isolated syndromes[J].Lancet Neurology,2012,11(2):157-169.
• [2]POLMAN C H,REINGOLD S C,BANWELL B,et al.Diagnostic criteria for multiple sclerosis:2010 revisions to the Mc Donald criteria[J].Ann Neurol,2011,69(2):292-302.
• [3]O'NEILL B,GARDANI M,FINDLAY G,et al.Challenging behaviour and sleep cycle disorder following brain injury:a preliminary response to agomelatine treatment[J].Brain Inj,2014,28(3):378-381.
• [4]VINCETI G,ZINI A,NICHELLI P,et al.Sensory Loss Mimicking Cauda Equina Syndrome due to Cervical Spinal Lesion in a Patient with Clinically Isolated Syndrome[J].Case Rep Neurol,2012,4(2):97-100.
• [5]JAIN R S,HANDA R,VYAS A,et al.Clinically isolated syndrome presenting as paroxysmal dysarthria:a rare but typical presentation[J].Neurol Sci,2014,35(8):1313-1314.
• [6]VEROS K,BLIOSKAS S,KARAPANAYIOTIDES T,et al.Clinically isolated syndrome manifested as acute vestibular syndrome:bedside neuro-otological examination and suppression of transient evoked otoacoustic emissions in the differential diagnosis[J].Am J Otolaryngol,2014,35(5):683-686.
• [7]LIU Y,DUAN Y,YU C,et al.Clinical isolated syndrome:a 3-year follow-up study in China[J].Clin Neurol Neurosurg,2011,113(8):658-660.
• [8]LABIANO-FONTCUBERTA A,MARTNEZ-GINS M L,ALADRO Y,et al.A comparison study of cognitive deficits in radiologically and clinically isolated syndromes[J].Mult Scler,2016,22(2):250-253.
• [9]ANAGNOSTOULI M C,SOTIRCHOS E S,ZALONIS I,et al.Monosymptomatic clinically isolated syndrome with sudden sensorineural hearing loss:case report and critical review of the literature[J].Neurologist,2012,18(5):302-305.

文章评论(Comment)：