李静;董艳;张晶洁;潘鸿;

• 1:北京市昌平区中西医结合医院

摘要(Abstract)：

目的探讨小儿肺热咳喘口服液对小儿毛细支气管炎Th1/Th2细胞的影响。方法选择2013年9月—2014年12月北京市昌平区中西医结合医院儿科收治的毛细支气管炎住院患儿80例,按随机数字表法分为试验组和对照组,各40例。根据临床用药指南,两组患儿均给予抗感染和对症治疗,对照组患儿静脉滴注头孢曲松钠治疗,治疗组患儿在对照组基础上给予小儿肺热咳喘口服液治疗,疗程均为7 d。比较两组患儿临床疗效,治疗前后干扰素γ(IFN-γ)、白介素4(IL-4)水平及Th1细胞分数、Th2细胞分数、Th1/Th2细胞百分比变化,并观察治疗期间两组患儿不良反应发生情况。结果试验组患儿临床疗效优于对照组(P<0.05)。治疗前两组患儿血清IFN-γ、IL-4水平及Th1细胞分数、Th2细胞分数、Th1/Th2细胞百分比比较,差异无统计学意义(P>0.05);治疗后试验组患儿血清IFN-γ、IL-4水平及Th1细胞分数、Th2细胞分数、Th1/Th2细胞百分比低于对照组(P<0.05)。结论小儿肺热咳喘口服液治疗毛细支气管炎患儿临床疗效良好,可通过调节Th1/Th2细胞而增加患儿免疫功能。

关键词(KeyWords)： 毛细支气管炎;小儿肺热咳喘口服液;Th1-Th2平衡

Abstract:

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作者(Author): 李静;董艳;张晶洁;潘鸿;

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