孙兆庆;闫波;

• 1:山东大学齐鲁医学院
• 2:济宁医学院附属医院

摘要(Abstract)：

近年研究表明,自身免疫疾病在冠心病的发生发展过程中具有一定作用,但冠心病合并自身免疫疾病的病例报告非常少见。本文报道了1例冠心病伴抗着丝点抗体强阳性患者,提示临床医生接诊常见冠心病危险因素不典型但冠状动脉狭窄程度却呈进行性加重的患者时应警惕自身免疫疾病的存在,应注意结合患者临床表现及病史完善自身抗体检查,尽早明确诊断并指导临床制定合理的治疗方案,以改善患者预后。

关键词(KeyWords)： 冠心病;动脉粥样硬化;自身免疫疾病;抗着丝点抗体;病例报告

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 孙兆庆;闫波;

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DOI:

参考文献(References)：

• [1]XING Z,PEI J,TANG L,et al.Traditional cardiovascular risk factors and coronary collateral circulation:protocol for a systematic review and meta-analysis of case-control studies[J].Medicine(Baltimore),2018,97(17):E0417.DOI:10.1097/MD.0000000000010417.
• [2]DAI X,ZHANG D,WANG C,et al.The pivotal role of thymus in atherosclerosis mediated by immune and inflammatory response[J].Int J Med Sci,2018,15(13):1555-1563.DOI:10.7150/ijms.27238.eCollection 2018.
• [3]LIASKOS C,MAROU E,SIMOPOULOU T,et al.Diseaserelated autoantibody profile in patients with systemic sclerosis[J].Autoimmunity,2017,50(7):414-421.DOI:10.1080/08916934.2017.1357699.
• [4]TAN E M,RODNAN G P,GARCIA I,et al.Diversity of antinuclear antibodies in progressive systemic sclerosis.Anti-centromere antibody and its relationship to CREST syndrome[J].Arthritis Rheum,1980,23(6):617-625.
• [5]ARAKAWA Y,AMAKI S,MIYAKAWA H,et al.PBC-AIHoverlap syndrome with concomitant ITP and Hashimoto's disease with positivity for anti-centromere antibody[J].J Gastroenterol,2004,39(5):490-495.DOI:10.1007/s00535-003-1322-5.
• [6]CERINIC M M,VALENTINI G,SORANO G G,et al.Blood coagulation,fibrinolysis,and markers of endothelial dysfunction in systemic sclerosis[J].Semin Arthritis Rheum,2003,32(5):285-295.DOI:10.1053/sarh.2002.50011.
• [7]SORIANO A,AFELTRA A,SHOENFELD Y.Is atherosclerosis accelerated in systemic sclerosis?Novel insights[J].Curr Opin Rheumatol,2014,26(6):653-657.DOI:10.1097/BOR.0000000000000115.
• [8]BELCH J J,MCSWIGGAN S,LAU C.Macrovascular disease in systemic sclerosis:the tip of an iceberg?[J].Rheumatology(Oxford),2008,47(Suppl 5):v16-17.DOI:10.1093/rheumatology/ken280.
• [9]GRAINGER D J,BETHELL H W.High titres of serum antinuclear antibodies,mostly directed against nucleolar antigens,are associated with the presence of coronary atherosclerosis[J].Ann Rheum Dis,2002,61(2):110-114.
• [10]LIANG K P,KREMERS H M,CROWSON C S,et al.Autoantibodies and the risk of cardiovascular events[J].J Rheumatol,2009,36(11):2462-2469.DOI:10.3899/jrheum.090188.
• [11]MAJKA D S,CHANG R W.Is preclinical autoimmunity benign?:The case of cardiovascular disease[J].Rheum Dis Clin North Am,2014,40(4):659-668.DOI:10.1016/j.rdc.2014.07.006.
• [12]PADJAS A,PLAZAK W,CELINSKA-LOWENHOFF M,et al.Myocardial ischaemia,coronary atherosclerosis and pulmonary pressure elevation in antiphospholipid syndrome patients[J].Adv Clin Exp Med,2016,25(6):1199-1205.DOI:10.17219/acem/63753.
• [13]毕嘉琛,刘志刚,刘晓程.冠状动脉粥样硬化性心脏病的自身免疫机制[J].免疫学杂志,2017,33(5):448-451.DOI:10.13431/j.cnki.immunol.j.20170080.

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