盐酸氟桂利嗪治疗偏头痛的临床疗效及其对血浆降钙素基因相关肽水平的影响Clinical Effect of Flunarizine Hydrochloride on Migraine Disorders and Its Impact on Plasma Calcitonin Gene-related Peptide Level
张绿明;邱石;李芹;吴涛;杜继臣;
摘要(Abstract):
目的分析盐酸氟桂利嗪治疗偏头痛的临床疗效及其对血浆降钙素基因相关肽(CGRP)水平的影响。方法选取2014年8月—2018年12月航天中心医院神经内科头痛门诊及住院病房收治的偏头痛患者45例,随访至第30天时根据随访日记将头痛发作频次≥3次/月的24例患者纳入研究并开始给予盐酸氟桂利嗪进行预防性治疗,连续治疗30 d。24例患者中5例未能完成试验、1例因出现哮喘而退出试验,最终共18例患者完成试验。比较18例患者用药前及用药30 d后头痛发作情况[包括头痛发作频次、头痛程度、视觉模拟评分法(VAS)评分及头痛持续时间],并记录用药期间不良反应发生情况;比较8例患者用药前及用药30 d后血浆CGRP水平。结果 (1)18例患者用药前与用药30 d后头痛程度和头痛持续时间比较,差异无统计学意义(P>0.05);用药30 d后头痛发作频次和VAS评分低于用药前(P<0.05)。(2)8例患者用药30 d后血浆CGRP水平低于用药前(P<0.05)。(3)18例患者治疗期间均未出现明显不良反应。结论盐酸氟桂利嗪可有效降低偏头痛患者头痛发作频率及强度,其机制可能与降低血浆CGRP水平有关。
关键词(KeyWords): 偏头痛;氟桂利嗪;降钙素基因相关肽;治疗结果
基金项目(Foundation): 航天中心医院青年创新基金项目(2016QN02)
作者(Author): 张绿明;邱石;李芹;吴涛;杜继臣;
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DOI:
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