任宏娜;孙惠敏;李静;

• 1:河北省唐山市中医医院检验科
• 2:河北省唐山市中医医院肺系病科

摘要(Abstract)：

诺卡菌引起的肺部感染较为少见且培养时间长易漏诊,其临床表现、影像学无特异性,临床对该疾病也缺乏足够认识,对患者症状缓解后即停药,导致患者感染反复发作。本文旨在分析1例支气管扩张并发南非诺卡菌肺部感染患者的诊断及治疗,并综合既往文献以提高临床医生和检验人员对诺卡菌的认识,以期早期诊断和有效治疗防止患者病情恶化。

关键词(KeyWords)： 支气管扩张;细菌感染;诺卡菌;诺卡菌感染;肺部感染;病例报告

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 任宏娜;孙惠敏;李静;

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参考文献(References)：

• [1]SHIVAPRAKASH M R,RAO P,MANDAL J,et al.Nocardiosis in a tertiary care hospital in North India and review of patients reported from India[J].Mycopathologia,2007,163(5):267-274.DOI:10.1007/s11046-007-9011-1.
• [2]PINTADO V,GóMEZ-MAMPASO E,FORTúN J,et al.Infection with Nocardia species:clinical spectrum of disease and species distribution in Madrid,Spain,1978-2001[J].Infection,2002,30(6):338-340.DOI:10.1007/s15010-002-2127-9.
• [3]孙渭歌，侯雪新，徐帅，等.快速鉴定诺卡菌的多重聚合酶链反应的建立[J].微生物与感染，2014,9(2):107-111.SUN W G,HOU X X,XU S,et al.Establishment of multiple polymerase chain reaction detection method for Nocardia[J].Journal of Microbes and Infections,2014,9(2):107-111.
• [4]罗玉玲，刘升明.诺卡菌病3例[J].中国感染与化疗杂志，2019,19(1):92-95.DOI:10.16718/j.1009-7708.2019.01.018.LUO Y L,LIU S M.Pulmonary nocardiosis:report of 3 cases[J].Chinese Journal of Infection and Chemotherapy,2019,19(1):92-95.DOI:10.16718/j.1009-7708.2019.01.018.
• [5]KANDI V.Human Nocardia infections:a review of pulmonary nocardiosis[J].Cureus,2015,7(8):e304.DOI:10.7759/cureus.304.
• [6]张媛，张媛媛，李振军，等.诺卡氏菌研究进展[J].中国人兽共患病学报，2012,28(6):628-634.ZHANG Y,ZHANG Y Y,LI Z J,et al.Research progress on Nocardia[J].Chinese Journal of Zoonoses,2012,28(6):628-634.
• [7]REDDY A K,GARG P,KAUR I.Speciation and susceptibility of Nocardia isolated from ocular infections[J].Clin Microbiol Infect,2010,16(8):1168-1171.DOI:10.1111/j.1469-0691.2009.03079.x.
• [8]SCHLABERG R,FISHER M A,HANSON K E.Susceptibility profiles of Nocardia isolates based on current taxonomy[J].Antimicrob Agents Chemother,2014,58(2):795-800.DOI:10.1128/AAC.01531-13.
• [9]CONVILLE P S,BROWN J M,STEIGERWALT A G,et al.Nocardia wallacei sp.nov.and Nocardia blacklockiae sp.nov.,human pathogens and members of the"Nocardia transvalensis Complex"[J].J Clin Microbiol,2008,46(4):1178-1184.DOI:10.1128/JCM.02011-07.
• [10]PIJPER A,PULLINGER B D.South African nocardiases[J].Trop Med Hyg,1927,30:153-156.
• [11]WAKAMATSU K,NAGATA N,KUMAZOE H,et al.Nocardia transvalensis pulmonary infection in an immunocompetent patient with radiographic findings consistent with nontuberculous mycobacterial infections[J].J Infect Chemother,2011,17(5):716-719.DOI:10.1007/s10156-011-0243-0.
• [12]苑美玉.1例星形诺卡菌引起肺内感染的病例分析[J].国际检验医学杂志，2014,35(20):2858-2859.
• [13]SINGH A,CHHINA D,SONI R K,et al.Clinical spectrum and outcome of pulmonary nocardiosis:5-year experience[J].Lung India,2016,33(4):398-403.DOI:10.4103/0970-2113.184873.
• [14]程振娜，李刚，师志云，等.诺卡菌感染的临床特点分析[J].宁夏医科大学学报，2017,39(5):537-540.DOI:10.16050/j.cnki.issn1674-6309.2017.05.012.CHENG Z N,LI G,SHI Z Y,et al.Clinical characteristics of Nocardia infection[J].Journal of Ningxia Medical University,2017,39(5):537-540.DOI:10.16050/j.cnki.issn1674-6309.2017.05.012.
• [15]VALDEZATE S,GARRIDO N,CARRASCO G,et al.Resistance gene pool to co-trimoxazole in non-susceptible Nocardia strains[J].Front Microbiol,2015,6:376.DOI:10.3389/fmicb.2015.00376.
• [16]MATIN A,SHARMA S,MATHUR P,et al.Myelosuppressionsparing treatment of central nervous system nocardiosis in a multiple myeloma patient utilizing a tedizolid-based regimen:a case report[J].Int J Antimicrob Agents,2017,49(4):488-492.DOI:10.1016/j.ijantimicag.2016.11.032.
• [17]ESCHAPASSE E,HUSSENET C,BERGERON A,et al.Respiratory infections caused by slow-growing bacteria:Nocardia,Actinomyces,Rhodococcus[J].Rev Mal Respir,2017,34(6):661-671.DOI:10.1016/j.rmr.2017.02.004.
• [18]肖立卫.诺卡菌感染确诊病例的药学思考[J].中国药物滥用防治杂志，2019,25(4):229-232.DOI:10.15900/j.cnki.zylf1995.2019.04.011.XIAO L W.Pharmacy thinking on the confirmed cases of Nocardia infection[J].Chinese Journal of Drug Abuse Prevention and Treatment,2019,25(4):229-232.DOI:10.15900/j.cnki.zylf1995.2019.04.011.
• [19]中国医药教育协会感染疾病专业委员会.抗菌药物药代动力学/药效学理论临床应用专家共识[J].中华结核和呼吸杂志，2018,41(6):409-446.DOI:10.3760/cma.j.issn.1001-0939.2018.06.004.

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