N端脑钠肽前体对老年慢性心力衰竭的诊断价值Diagnostic Value of N-terminal Probrain Natriuretic Peptide in Chronic Heart Failure of The Elderly Patients
张效明;张鹏;王廷涛;冯崴;
摘要(Abstract):
目的探讨老年慢性心力衰竭(CHF)患者血浆脑钠肽前体(NT-proBNP)水平与左室功能的关系及临床意义。方法将93例老年CHF患者按美国心脏病协会(NYHA)分级方法分为心功能Ⅱ、Ⅲ、Ⅳ级3组,25名健康老年人纳入对照组。采用电化学发光免疫分析技术测定4组血浆NT-proBNP水平,用超声心动图测定左室舒张末期内径(LVEDD)和左心室射血分数(LVEF)。结果心力衰竭NT-proBNP、LVEDD显著高于对照组(P<0.01),且血清NT-proBNP浓度随着心功能分级的增加而升高(3组两两比较均有统计学意义,P<0.01)。NT-proBNP水平与LVEDD呈正相关(r=0.711,P<0.01),而与LVEF呈负相关(r=-0.85,P<0.01)。结论血浆NT-proBNP水平可作为CHF患者心功能检测的有效生化指标,可以用来评估老年心力衰竭患者的左室功能。
关键词(KeyWords): 心力衰竭,充血性;心室功能,左;超声心动描记术
基金项目(Foundation):
作者(Author): 张效明;张鹏;王廷涛;冯崴;
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DOI:
参考文献(References):
- 1 Sudoh T,Kangwa K,Minamino N,et al.A natriuretic peptide in por-cine brain[J].Nature,1988,322:78-81.
- 2 Seino Y,Ogawa A,Yamashite T,et al.Application of NT-proBNPand BNP measurements in cardiac care:a more discerning marker for thedetection and evaluation of heart failure[J].Eur J Heart Fail,2004,6:295-300.
- 3 Ishii J.Clinical utility ofNT-proBNP,a new biomarker of cardiacfunction and heart failure[J].Jpn J Clin Patho,l 2008,56(4):316-321.
- 4 Michele E,Claudio P,Concetta P,et al.Comparison ofbrain natri-uretie peptide(BNP)and amino-terminal ProBNP for early diagnosisof heart failure[J].Clin Chem,2007,53:1289-1297.
- 5 Sudoh T,Kangawa K,Minamino N,et al.A new natriuretic peptidein porcine brain[J].Nature,1988,322(3):78-81.
- 6 Hopkins W E,Chen Z,Fukagawa N K,et al.Increased atrial andbrain natriuretic peptides in adults with congebital heart disease:en-hanced understanding of the relationship between hypoxia and natriureticpeptide secretion[J].Circulation,2004,109(23):2872.
- 7张燕,李殿富.充血性心力衰竭患者血浆N末端脑钠肽前体水平与心功能关系的探讨[J].标记免疫分析与临床,2009,16(6):329-331.
- 8赵丽,吴学思,韩智红,等.B型钠利尿肽检测对心力衰竭患者的临床评估[J].中华心血管病杂志,2004,32(1):51-52.
- 9 Maisel A.B-type natriuretic peptide levels:a potential novel"whitecount"of congestive heart failure[J].J Card Fail,2001,7(2):183-193.
- 10 De Lemos JA,McGuire DK,DraznerMH.B type natriuretic peptidein cardiovascular disease[J].Lancet,2003;362:316-322.
- 11 Seino Y,Ogawa A,Yamashita T,et al.Application ofNT-proBNPand BNP measurements in cardiac care a more disceming marker for thedetection and evalution of heart failure[J].Eur J Heart Fai,l 2004,6(5):295-300.
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