李哲贤;宋伟强;刘袁颖;武德梅;邢建华;

• 1:中国石油天然气总公司中心医院保健与老年医学科

摘要(Abstract)：

目的比较多系统萎缩P型(MSA-P型)与帕金森病患者的临床特征及认知功能。方法选取2012年7月—2014年8月中国石油天然气总公司中心医院收治的MSA-P型患者31例作为A组,帕金森病患者53例作为B组。比较两组患者临床特征、运动功能、日常行为能力、认知功能、智力及记忆力。结果两组患者智能障碍发生率比较,差异无统计学意义(P>0.05);A组患者首发震颤发生率、锥体外系症状发生率低于B组,行走困难发生率、语言障碍发生率、小脑症状发生率、美多巴治疗无效率、锥体束症状发生率、性功能异常发生率、排尿异常发生率、直立性低血压发生率高于B组(P<0.05)。A组患者帕金森综合评分量表Ⅲ(UPDRS-Ⅲ)评分、日常生活活动能力量表(ADL)评分高于B组(P<0.05)。A组简易智能精神状态检查量表(MMSE)评分低于B组(P<0.05)。两组患者命名评分、注意力评分、语言评分、抽象能力评分、记忆评分、定向力评分及蒙特利尔认知评估量表(Mo CA)总评分比较,差异无统计学意义(P>0.05);A组患者视空间/执行功能评分低于B组(P<0.05)。A组患者操作量表评分低于B组(P<0.05);两组患者中国修订韦氏成人智力量表(WAIS-RC)总评分、言语量表评分比较,差异无统计学意义(P>0.05)。两组患者视觉再认评分、相似性评分、数字广度评分比较,差异无统计学意义(P>0.05);A组患者视觉再生评分、理解记忆评分、图形排列评分、积木测试评分、韦氏成人记忆量表总评分低于B组(P<0.05)。结论 MSA-P型与帕金森病患者临床特征及认知功能存在差异,与帕金森病患者比较,MSA-P型患者认知功能、智力及记忆力较差。

关键词(KeyWords)： 多系统萎缩;帕金森病;认知障碍

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 李哲贤;宋伟强;刘袁颖;武德梅;邢建华;

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参考文献(References)：

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