王敏珊,吴峰

• 1:广东医科大学
• 2:广东省惠州市第三人民医院呼吸内科

摘要(Abstract)：

支气管哮喘是一种复杂的异质性疾病，具有许多临床和生物学表现，涉及多种潜在的病理生理机制。近几十年来，支气管哮喘的生物标志物已成功用于疾病的诊治与监测。在临床上，有各种有创和无创的血液和气道检测方法来评估高T2型支气管哮喘。本文综述了高T2型支气管哮喘的发病机制及其生物标志物，以期为支气管哮喘的临床诊疗提供参考。

关键词(KeyWords)： 支气管哮喘;生物标志物;综述

Abstract:

Keywords:

基金项目(Foundation): 广东省卫生健康适宜技术推广项目(793)

作者(Author): 王敏珊,吴峰

参考文献(References)：

• [1]谢佳星，赖克方.加强中国基层医院支气管哮喘的规范化诊疗[J].国际呼吸杂志，2023，43(12)：1378-1382.DOI：10.3760/cma.j.cn131368-20231119-00343.
• [2]HABIB N，PASHA M A，TANG D D.Current understanding of asthma pathogenesis and biomarkers[J].Cells，2022，11(17)：2764.DOI：10.3390/cells11172764.
• [3]KURUVILLA M E，EUN-HYUNG LEE F，LEE G B.Understanding asthma phenotypes，endotypes，and mechanisms of disease[J].Clin Rev Allergy Immunol，2019，56(2)：219-233.DOI：10.1007/s12016-018-8712-1.
• [4]BRUSSELLE G G，KOPPELMAN G H.Biologic therapies for severe asthma[J].N Engl J Med，2022，386(2)：157-171.DOI：10.1056/NEJMra2032506.
• [5]RUNNSTROM M，PITNER H，XU J，et al.Utilizing predictive inflammatory markers for guiding the use of biologicals in severe asthma[J].J Inflamm Res，2022，15：241-249.DOI：10.2147/JIR.S269297.
• [6]HAMMAD H，LAMBRECHT B N.The basic immunology of asthma[J].Cell，2021，184(9)：2521-2522.DOI：10.1016/j.cell.2021.04.019.
• [7]朱桂萍，叶伶，金美玲.支气管哮喘靶向治疗的研究进展[J].国际呼吸杂志，2021，41(7)：529-535.DOI：10.3760/cma.j.cn131368-20200619-00524.
• [8]PIN I，GIBSON P G，KOLENDOWICZ R，et al.Use of induced sputum cell counts to investigate airway inflammation in asthma[J].Thorax，1992，47(1)：25-29.DOI：10.1136/thx.47.1.25.
• [9]张亚丽，蒋毅.诱导痰检测技术在支气管哮喘中的应用进展[J].山东医药，2022，62(7)：93-96.DOI：10.3969/j.issn.1002-266X.2022.07.024.
• [10]JAYARAM L，PIZZICHINI M M，COOK R J，et al.Determining asthma treatment by monitoring sputum cell counts：effect on exacerbations[J].Eur Respir J，2006，27(3)：483-494.DOI：10.1183/09031936.06.00137704.
• [11]CABALLERO M L，DOMINGUEZ-ORTEGA J，NIN-VALENCIA A R，et al.Eosinophil count could be more sensitive in induced sputum than in peripheral blood for phenotyping of patients with severe eosinophilic asthma[J].J Investig Allergol Clin Immunol，2021，31(4)：360-361.DOI：10.18176/jiaci.0647.
• [12]ABDO M，PEDERSEN F，KIRSTEN A M，et al.Longitudinal impact of sputum inflammatory phenotypes on small airway dysfunction and disease outcomes in asthma[J].J Allergy Clin Immunol Pract，2022，10(6)：1545-1553.e2.DOI：10.1016/j.jaip.2022.02.020.
• [13]POPOVI?-GRLE S，?TAJDUHAR A，LAMPALO M，et al.Biomarkers in different asthma phenotypes[J].Genes，2021，12(6)：801.DOI：10.3390/genes12060801.
• [14]陈雪琴，张明顺，黄茂，等.嗜酸粒细胞性哮喘生物标志物的研究进展[J].南京医科大学学报(自然科学版)，2022，42(5)：734-739.DOI：10.7655/NYDXBNS20220522.
• [15]WAGENER A H，DE NIJS S B，LUTTER R，et al.External validation of blood eosinophils，FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma[J].Thorax，2015，70(2)：115-120.DOI：10.1136/thoraxjnl-2014-205634.
• [16]CASCIANO J，KRISHNAN J A，SMALL M B，et al.Value of peripheral blood eosinophil markers to predict severity of asthma[J].BMC Pulm Med，2016，16(1)：109.DOI：10.1186/s12890-016-0271-8.
• [17]杨春霞.外周血嗜酸性粒细胞计数对哮喘发作频率的影响[D].广东：广东医科大学，2023.
• [18]杨文聪，潘振.支气管哮喘患儿外周血IgG4 TIM4 MMP-12及嗜酸性粒细胞的表达特点与意义[J].中国妇幼保健，2024，39(22)：4404-4408.DOI：10.19829/j.zgfybj.issn.1001-4411.2024.22.012.
• [19]LEE J H，KIM T B.Eosinophil granule proteins：what they can tell us about asthma[J].Thorax，2022，77(6)：532-533.DOI：10.1136/thoraxjnl-2021-218268.
• [20]VERNET R，MATRAN R，ZERIMECH F，et al.Identification of novel genes influencing eosinophil-specific protein levels in asthma families[J].J Allergy Clin Immunol，2022，150(5)：1168-1177.DOI：10.1016/j.jaci.2022.05.017.
• [21]KIM C K，CALLAWAY Z，PAWANKAR R.Eosinophil granule proteins as a biomarker in managing asthma and allergies[J].Asia Pac Allergy，2023，13(2)：66-71.DOI：10.5415/apallergy.0000000000000104.
• [22]中华医学会血液学分会白血病淋巴瘤学组.中国嗜酸性粒细胞增多症诊断和治疗指南(2024版)[J].中华血液学杂志，2024，45(1)：1-7.DOI：10.3760/cma.j.cn121090-20231222-00334.
• [23]ESCAMILLA-GIL J M，FERNANDEZ-NIETO M，ACEVEDO N.Understanding the cellular sources of the fractional exhaled nitric oxide (FeNO) and its role as a biomarker of type 2 inflammation in asthma[J].Biomed Res Int，2022，2022：5753524.DOI：10.1155/2022/5753524.
• [24]YATERA K，MUKAE H.Possible pathogenic roles of nitric oxide in asthma[J].Respir Investig，2019，57(4)：295-297.DOI：10.1016/j.resinv.2019.03.007.
• [25]GAO J，WU F.Association between fractional exhaled nitric oxide，sputum induction and peripheral blood eosinophil in uncontrolled asthma[J].Allergy Asthma Clin Immunol，2018，14：21.DOI：10.1186/s13223-018-0248-7.
• [26]SMITH A D，COWAN J O，BRASSETT K P，et al.Use of exhaled nitric oxide measurements to guide treatment in chronic asthma[J].N Engl J Med，2005，352(21)：2163-2173.DOI：10.1056/NEJMoa043596.
• [27]LOEWENTHAL L，MENZIES-GOW A.FeNO in asthma[J].Semin Respir Crit Care Med，2022，43(5)：635-645.DOI：10.1055/s-0042-1743290.
• [28]COUILLARD S，LAUGERUD A，JABEEN M，et al.Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide[J].Thorax，2022，77(2)：199-202.DOI：10.1136/thoraxjnl-2021-217325.
• [29]NOVOSAD J，KR?MOVá I.Evolution of our view on the IgE molecule role in bronchial asthma and the clinical effect of its modulation by omalizumab：where do we stand today?[J].Int J Immunopathol Pharmacol，2020，34：2058738420942386.DOI：10.1177/2058738420942386.
• [30]CARROLL W D，LENNEY W，CHILD F，et al.Asthma severity and atopy：how clear is the relationship?[J].Arch Dis Child，2006，91(5)：405-409.DOI：10.1136/adc.2005.088278.
• [31]TANAKA A，JINNO M，HIRAI K，et al.Longitudinal increase in total IgE levels in patients with adult asthma：an association with poor asthma control[J].Respir Res，2014，15(1)：144.DOI：10.1186/s12931-014-0144-8.
• [32]PALOMARES ó，SáNCHEZ-RAMóN S，DáVILA I，et al.dIvergEnt：how IgE axis contributes to the continuum of allergic asthma and anti-IgE therapies[J].Int J Mol Sci，2017，18(6)：1328.DOI：10.3390/ijms18061328.
• [33]BOUSQUET J，HUMBERT M，GIBSON P G，et al.Real-world effectiveness of omalizumab in severe allergic asthma：a meta-analysis of observational studies[J].J Allergy Clin Immunol Pract，2021，9(7)：2702-2714.DOI：10.1016/j.jaip.2021.01.011.
• [34]LI B H，HUANG M Y，HUANG S Y，et al.Prediction of clinical response to omalizumab in moderate-to-severe asthma patients using the change in total serum IgE level[J].J Thorac Dis，2020，12(12)：7097-7105.DOI：10.21037/jtd-20-2073.
• [35]WESTERHOF G A，KOREVAAR D A，AMELINK M，et al.Biomarkers to identify sputum eosinophilia in different adult asthma phenotypes[J].Eur Respir J，2015，46(3)：688-696.DOI：10.1183/09031936.00012415.
• [36]MATSUMOTO H.Roles of periostin in asthma[J].Adv Exp Med Biol，2019，1132：145-159.DOI：10.1007/978-981-13-6657-4_15.
• [37]SONNENBERG-RIETHMACHER E，MIEHE M，RIETHMACHER D.Periostin in allergy and inflammation[J].Front Immunol，2021，12：722170.DOI：10.3389/fimmu.2021.722170.
• [38]WOODRUFF P G，BOUSHEY H A，DOLGANOV G M，et al.Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids[J].Proc Natl Acad Sci USA，2007，104(40)：15858-15863.DOI：10.1073/pnas.0707413104.
• [39]LIU Y，FU L，LIU Z.The role and clinical relevance of osteopontin in allergic airway diseases[J].J Clin Med，2023，12(6)：2433.DOI：10.3390/jcm12062433.
• [40]SHAKHOVA N V.Periostin as a biomarker of bronchial asthma[J].Vopr Sovr Pediatr，2020，18(5)：339-345.DOI：10.15690/vsp.v18i5.2056.
• [41]TAKAHASHI K，MEGURO K，KAWASHIMA H，et al.Serum periostin levels serve as a biomarker for both eosinophilic airway inflammation and fixed airflow limitation in well-controlled asthmatics[J].J Asthma，2019，56(3)：236-243.DOI：10.1080/02770903.2018.1455855.
• [42]BALDO D C，ROMALDINI J G，PIZZICHINI M M M，et al.Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients[J].J Bras Pneumol，2023，49(1)：e20220040.DOI：10.36416/1806-3756/e20220040.
• [43]BUHL R，KORN S，MENZIES-GOW A，et al.Prospective，single-arm，longitudinal study of biomarkers in real-world patients with severe asthma[J].J Allergy Clin Immunol Pract，2020，8(8)：2630-2639.e6.DOI：10.1016/j.jaip.2020.03.038.
• [44]ALZOBAIDI N，REHMAN S，NAQVI M，et al.Periostin：a potential biomarker and therapeutic target in pulmonary diseases[J].J Pharm Pharm Sci，2022，25：137-148.DOI：10.18433/jpps32306.

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