非奈利酮在糖尿病肾病中的应用进展Application Progress of Finerenone in Diabetic Kidney Disease
李雯静,杨小娟
摘要(Abstract):
糖尿病肾病(DKD)是糖尿病的严重并发症,心血管事件和终末期肾脏病(ESRD)是DKD患者死亡的主要原因。近20年来,降糖、降脂和阻断肾素-血管紧张素-醛固酮系统(RAAS)治疗虽然可以降低DKD患者尿蛋白,抑制其肾脏纤维化,但对肾脏和心血管结局的改善作用有限。研究表明,盐皮质激素受体(MR)过度活化可触发炎症和肾脏纤维化,导致DKD进展。非奈利酮是一种新型非甾体类盐皮质激素受体拮抗剂(MRA),其可以使DKD患者心肾双重获益。本研究主要综述了MRA治疗DKD的机制及非奈利酮治疗DKD的有效性、安全性,以期为非奈利酮治疗DKD提供证据支持。
关键词(KeyWords): 糖尿病肾病;盐皮质激素受体拮抗剂;非奈利酮;综述
基金项目(Foundation):
作者(Author): 李雯静,杨小娟
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